After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen

Saturday, 24 March 2012
The Unforgettable Brain of an Amnesiac


The person who probably contributed more to our understanding of human memory than anyone else was Henry Molaison, who died on December 2, 2008 at the age of 82. No, Molaison wasn’t a neurologist. He was a patient who had both hippocampi surgically removed from his brain in 1953, when he was 27 years old, in an effort to reduce his severe epileptic seizures.

The operation succeeded in controlling his epilepsy, but had an unforeseen side effect: it took away his ability to remember new information about his life and the world (declarative memory). as well, thus revealing the extremely important role that the hippocampus plays in long-term memory. Subsequently, H.M. became the most studied patient in the history of neuroscience (he is known by his initials to protect his privacy), and he will continue to be studied for some time. Almost a year to the day after he died, his brain was sliced into nearly 2600 thin sections, which were than stained and captured in digital images that can now be accessed free of charge on the Internet.

Because H.M.’s anterograde amnesia was extremely well documented in terms of his psychological capabilities, researchers may spend many years to come looking for correlations between these capabilities and the particular anatomy of his brain.

i_lien The Man Who Couldn’t Remember
i_lien H. M., an Unforgettable Amnesiac, Dies at 82
i_lien L’incroyable parcours du cerveau d’Henry Molaison
i_lien Project H.M., Phase I
i_lien HM (patient)
a_lien H.M. Project

Memory and the Brain | 1 comment

One comment at; “The Unforgettable Brain of an Amnesiac”

  1. Bruno Dubuc says:

    Postmortem examination of patient H.M.’s brain based on histological sectioning and digital 3D reconstruction