After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Tuesday, 22 December 2015
Some Interesting Links

This week, I’m offering you my own little holiday present: links on two subjects that we’ve already explored in this blog several times before, simply because they’re so fascinating.

The first link takes you to an annual episode of the Brain Science Podcast in which the episodes posted during the year are reviewed. For example, that year the podcast’s host, Ginger Campbell, discussed brain plasticity with Michael Merzenich, the links between cognition and emotion with Luis Pessoa, sleep with Penny Lewis, consciousness with Michael Graziano, the benefits that physical exercise has for the brain with John Ratey, and mirror neurons with Greg Hickok. (more…)

From the Simple to the Complex | No comments


Thursday, 12 November 2015
From membrane excitability to subjective consciousness

When people tell me that they’d like to understand more about how their brain works, I often respond teasingly that first they should probably ask what they use it for. Because you don’t use your brain only for its obvious, “proximal” functions, such as thinking, talking, understanding, laughing, crying, riding a bicycle, philosophizing, and simultaneously being aware of doing all those things. In that sense, unhelpful as this answer may seem, you actually use your brain for everything: everything you do, including sleeping or daydreaming, involves co-ordinated activity on the part of your brain.

No, what I’m talking about is the brain’s ”distal” (ultimate) function. In other words, how and for what reason did the first nervous systems evolve? (more…)

From the Simple to the Complex | No comments


Thursday, 15 October 2015
Inhibitory Neurons: More Than Just a Brake

Neuroscientists have known that the brain contains glial cells just as long as they have known that it contains neurons, but only in the past two or three decades have scientists discovered the actual importance of glial cells for communication within the brain. Similarly, neuroscientists have long known that between the large excitatory neurons of the cerebral cortex, there are a multitude of small inhibitory neurons. Once thought to act as simple “brakes” on brain activity, these inhibitory neurons have gradually been found to display far more complex variations in their nature, form, connectivity and function than was originally believed. (more…)

Mental Disorders | No comments


Tuesday, 22 September 2015
Seeing without knowing it : the strange phenomenon of blindsight

This week I’d like to share some information about the fascinating phenomenon of blindsight, along with links to other articles on this subject. People can become blind as the result of damage to the retina, but in rarer cases blindness can occur when both sides of the visual cortex are damaged. The latter situation can lead to the strange phenomenon known as blindsight or unconscious vision, in which people believe that they can’t see anything, but can nevertheless correctly identify the positions of objects in space. If you ask these people where a certain object or point of light is, they will say they don’t know, but if you insist and ask them to take a chance, guess, and point in the direction where they think the object or light might be, most of the time, they’ll point in the right direction. (more…)

The Senses | No comments


Tuesday, 1 September 2015
Memory Loss in Alzheimer’s Reduced for the First Time

On November 4, 1906, German neurologist Alois Alzheimer first described the “particular malady of the cerebral cortex” of his patient Auguste D. Over a century later, this “particular malady” that now bears his name still resists every medication developed so far to treat it: none has yet succeeded in halting the progress of Alzheimer’s disease, or even in slowing it down. At best, some medications reduce some of the disease’s symptoms. In the past decade alone, an estimated $1 billion has been swallowed up by clinical trials of new Alzheimer’s medications, with almost nothing to show for them.

But after decades of disappointment, the tide may be turning at last.  A preliminary study published in September 2014 by Dr. Dale Bredesen, in the journal Aging, suggests that the memory losses associated with Alzheimer’s can be reversed through an elaborate 36-point treatment program including dietary changes, exercise, intellectual stimulation and other activities that had already been recognized as Alzheimer’s prevention factors separately. But in this case, it is the unusual step of combining them that seems to have curative value. (more…)

Mental Disorders, Uncategorized | No comments