After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen

Monday, 21 November 2022
Zebrafish brain images may reveal neuronal bases of emotional memory

As is well known, memories with heavy emotional connotations—especially negative ones—are very strong. In extreme cases of post-traumatic stress, such memories can be so recurrent and intrusive that they make life a living hell. In mammals, the brain structure most highly involved in such negative memories is the amygdala. But while much research has been done on the hippocampus, which is the brain structure involved in spatial, lexical and other forms of memory, the amygdala has received much less attention, in part because it is so hard to access. To get around this problem, a research team at the University of Southern California, in Los Angeles, used larval zebrafish and a fluorescence-based imaging method to visualize the changes that occurred in the synapses of the pallium (the fish brain structure equivalent to the amygdala) after aversive conditioning. The surprising results were published in the journal PNAS in January 2022, in an article entitled “Regional synapse gain and loss accompany memory formation in larval zebrafish”. (more…)

Memory and the Brain | Comments Closed