After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Wednesday, 23 April 2025
Our two ways of thinking and the inhibition of the frontal cortex

The human brain is often described as having two main ways of thinking: one of them fast, automatic and unconscious, the other slower, more flexible and requiring conscious control. Each of them has its own benefits and drawbacks. The first—let’s call it “System 1”—is based on the sum of the habits, stereotypes and received ideas that we have acquired since childhood. System 1 doesn’t provide us with any ready-made solutions, but instead sends us down paths to possible or likely ones. In contrast, System 2, with its logical, rational thinking, is slower and more careful. It proceeds by deduction, inference and comparison. System 2 is what lets us see past our conditioning and beyond appearances. (more…)

From Thought to Language | Comments Closed


Monday, 4 June 2012
Stress, Prefrontal Cortex Inhibition, and Depression

stressExposure to chronic stress has many harmful effects, including effects on our cognition and mental health. The June 2009 edition of Nature Reviews Neuroscience presents several articles summarizing the most recent research findings on this subject.

One of these articles, by Amy F. T. Arnsten, shows how stress inhibits thinking, planning, and control activity in the prefrontal cortex, while strengthening the activity of the rapid reflex pathways connected to the amygdala and the subcortical structures associated with it. (more…)

Mental Disorders | Comments Closed