After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Wednesday, 8 April 2020
Spectacular advances in two-photon microscopy and two-photon calcium imaging

What if I told you that scientists had just succeeded in recording the simultaneous activity of 12 000 neurons in the cortex of a mouse as it moved freely around its cage, and that they had done so at the cellular level, down to a frequency of 17 Hertz? Would you say something like, “So what?” or “Who cares?” or “Why don’t you tell me in language I can understand?” In this post, I’m going to try to meet that last challenge. (more…)

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