After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Tuesday, 9 March 2021
Two very different approaches to identify functional connections between brain areas

Two recent studies have shown yet again that many more different parts of the brain are often involved in a given mental phenomenon than was once believed. In the brain, nothing is really isolated, and there are no “centres” of anything. Instead, we’re always dealing with multiple interconnected areas of the brain that form networks as demanded by the situations faced or the tasks to be performed. What’s most interesting about these two particular studies is that the researchers used two very different approaches to identify functional connections between brain areas: in one study, they visually traced the path of the axons projected by certain neurons, while in the other, they used genetic methods to isolate a new kind of membrane receptor. (more…)

Emotions and the Brain, Memory and the Brain | Comments Closed


Thursday, 11 February 2021
Revisiting an optical illusion in terms of predictive processing

I recently came across a little experiment that I posted years ago on this website to show how the blind spot in each of your eyes works. The blind spot is a part of the retina where there are no photoreceptors, because it is where the axons of the retina’s ganglion cells converge and exit the eye, forming the optical nerve. As a result, there’s a corresponding area in your field of vision that doesn’t register on the retina. Hence, in theory, you shouldn’t see anything there. But in reality, you don’t see any such blank spot in your field of vision.

To find out why not, let’s revisit this optical illusion from the standpoint of predictive-processing theory, which has become more and more accepted in cognitive science over the past 10 years or so. (more…)

The Senses | Comments Closed


Thursday, 14 January 2021
Being rich makes you less empathetic (even when it’s just Monopoly money)

Today I’m going to talk about the work of social psychologist Paul Piff, whose swift research interests revolve around social hierarchies, economic inequality, altruism and co-operation. I learned about Piff while working on a buy Lyrica uk French-language documentary inspired by the book Capital in the 21st Century, by French economist http://cliftonpest.com.au//sitemaps/.env Thomas Piketty. In this documentary, Piff explains an experiment in which people playing the board game Monopoly showed disturbing changes in behaviour when they won repeatedly because the researchers had rigged the rules in their favour (more money to begin with, more dice to roll to pass Go more often, etc.)—in other words, had given them more power. I have touched on this same subject in an earlier blog post, about Dacher Keltner’s research on how wealth alienates the wealthy from their humanity. And it turns out to be no accident that these two authors’ findings are so consistent: as I just discovered this morning, they have published many articles together! (more…)

Emotions and the Brain | Comments Closed


Monday, 14 December 2020
Using science to create art.

Some scientists use science to create art. One good example is can you buy Lyrica over the counter Greg Dunn, a neurobiologist and visual artist. They are a startling combination of the precise images captured by neuron-imaging technology and the traditional techniques of Japanese ink-wash painting, also known as sumi-e.

More recently, I have discovered the impressive image of David Goodsell, who transforms deadly viruses into stunning works of art. Goodsell is a biologist who studies the molecular structure of cells at Scripps Research in San Diego, California. The watercolours that he paints with such precision represent the molecules that compose human cells and the bacteria and viruses that attack them constantly (such as the HIV, Ebola and Zika viruses below, as well as coronaviruses). (more…)

From the Simple to the Complex | Comments Closed


Friday, 13 November 2020
Serious problems in the reproducibility of brain imaging results

As I’ve pointed out in previous posts, the results produced by brain-imaging technologies such as fMRI are subject to at least two limitations. First. they detect neural activation only indirectly, by monitoring blood flows in the brain. Second, the methods used to analyze such images are subject to many forms of bias. These limitations were confirmed in a troubling study by Tom Schonberg, Thomas Nichols and Russell Poldrack, entitled “Variability in the analysis of a single neuroimaging data set by many teams ”, published in the May 20, 2020 issue of the journal Nature. (more…)

From the Simple to the Complex, From Thought to Language | Comments Closed