After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen

Monday, 29 May 2023
How psychedelic drugs modulate brain activity

For many decades, the officially illegal status of psychedelic drugs such as LSD made research about them difficult. But more recently, studies done using various forms of brain imaging and in accordance with sound scientific practices have begun to show how these substances modulate brain activity to produce their surprising, varied effects. Broadly speaking, psychedelic drugs alter the functional connectivity between various parts of the brain while modulating the power of certain brain waves. The results are typical of the many cases in which molecules of a neuromodulating substance (in this case, an exogenous one) minimize the effects of certain natural neuromodulating systems by binding to their receptors—in the case of LSD, the receptors for dopamine and serotonin. (more…)

The Emergence of Consciousness | Comments Closed

Monday, 9 January 2017
A First Brain-Imaging Study on the Effects of LSD

“This is to neuroscience what the Higgs boson was to particle physics.”

This eye-catching remark comes from neuropsychopharmacologist David Nutt, and he is talking about a study on which he was the senior researcher: “Neural correlates of the LSD experience revealed by multimodal neuroimaging”, published in the journal Proceedings of the National Academy of Sciences in April 2016. And like the results of the research on the Higgs boson, the results of Nutt’s study confirmed the theory—in this case, that the observed changes in brain activity would provide a very good picture of the mental state produced by an “acid trip”. (more…)

The Emergence of Consciousness | No comments