After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Tuesday, 28 September 2021
Two pioneers in research on neurogenesis and vision

Today I just want to draw your attention to two researchers who are senior citizens but still active and still inspiring: Fred Gage and Deric Bownds.

Fred Gage recently gave an interview on his scientific career, in which he told how he became a pioneer in research on neurogenesis—the development of new neurons in the brains of adult mammals. It’s always interesting to learn about the scientific career of someone who disproved an idea that was previously dogma. In Gage’s case, it was the idea that had emerged during the last decades of the 20th century that when humans are born, their brains contain as many neurons as they will ever have and will only continue to lose them as their lives go on. (more…)

From the Simple to the Complex | Comments Closed


Monday, 17 December 2012
Neurogenesis and Depression

The processes leading to the many different illnesses that can affect people’s psychic equilibrium are still hotly debated. Often, these processes involve multiple contributing factors which is why there are so many different hypotheses about them. In the case of depression, for example, one of the best known is the monoamine hypothesis, which associates the disease with underactivity of certain neurotransmitters. such as serotonin.

Several research laboratories are now working on a more recent hypothesis about the cause of depression, involving a phenomenon that was first confirmed in humans in the late 1990s: neurogenesis, meaning the birth of new neurons in the adult brain. The starting point for this hypothesis is that these young neurons seem to show greater plasticity and are found only in certain parts of the brain, such as the dentate gyrus of the hippocampus, that are associated with emotions. (more…)

Memory and the Brain, Mental Disorders | 1 comment