After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Monday, 19 May 2025
Why does your brain consume so much energy?

Your brain accounts for only about 2% of your body weight, but 20 to 25% of all the oxygen and glucose that your body consumes. Why this vast disparity? Until about 20 years ago, people tended to think of the brain as an organ that waited passively for stimuli and then reacted to them. But more recent neuroscientific research paints a very different picture of the brain, as an organ constantly engaged in intrinsic, spontaneous activity. Metaphorically, people used to imagine the brain as a calm, flat body of water, onto which a drop of rain occasionally fell and created a few ripples. Now scientists have shown us that the brain is a place where it is always raining, so that when one drop of rain falls, the small disturbance that it creates merges into something larger that is already highly active.

This major paradigm shift originated in the observation that the brain generates neural activity patterns spontaneously, regardless of what is happening in the individual’s environment. In your earliest stages of development, you may see no apparent connection between these patterns and the world around you. But they become more meaningful as you grow, acquire experience and begin to see how your actions in certain situations affect the world around you.

From the Simple to the Complex | Comments Closed


Wednesday, 23 April 2025
Our two ways of thinking and the inhibition of the frontal cortex

The human brain is often described as having two main ways of thinking: one of them fast, automatic and unconscious, the other slower, more flexible and requiring conscious control. Each of them has its own benefits and drawbacks. The first—let’s call it “System 1”—is based on the sum of the habits, stereotypes and received ideas that we have acquired since childhood. System 1 doesn’t provide us with any ready-made solutions, but instead sends us down paths to possible or likely ones. In contrast, System 2, with its logical, rational thinking, is slower and more careful. It proceeds by deduction, inference and comparison. System 2 is what lets us see past our conditioning and beyond appearances. (more…)

From Thought to Language | Comments Closed


Monday, 17 March 2025
Frans de Waal’s legacy on “human nature”

I have just learned the sad news that the great Dutch primatologist Frans de Waal died in March 2024, at the age of 75. De Waal was both a fine researcher and a peerless communicator about his discipline to the general public.

As the United States continues its descent into techno-fascist oligarchy, many people are now rightly wondering what “human nature” is all about. De Waal did much to show that contrary to the theory of philosophers such as Thomas Hobbes, that human beings are fundamentally selfish and human morality is just a thin cultural veneer, human nature actually has deep evolutionary roots in empathy and reciprocity that are abundantly demonstrated by the behaviour of non-human primates and even of other mammals. The quote from de Waal that I was looking for this morning reveals that “human nature” is more complex and nuanced. We humans, with our brains three times the size of those of the chimpanzees and bonobos who are our closest living cousins, can be both more aggressive than the former (who sometimes gang up to kill isolated members of other groups) and more altruistic than the latter (who are well known for using sex to settle conflicts). (more…)

Uncategorized | Comments Closed


Monday, 24 February 2025
Truly amazing videos about the hippocampus

This week I want to encourage you to watch a video entitled “How Your Brain Chooses What To Remember”, at https://www.youtube.com/watch?v=ceFFEmkxTLg. This video is one of many posted on the YouTube channel of computational neuroscientist Arsem Kirsanov. Kirsanov worked in the laboratory of neurologist Gyorgy Buzsaki , and Kirsanov’s videos about the hippocampus are truly amazing—in particular the one that I just mentioned. Not only does it present the content and methodology of a recent scientific article that is fascinating in itself, but it does so using a brilliant instructional approach with outstanding visuals. (more…)

Memory and the Brain | Comments Closed


Friday, 31 January 2025
Humans: The species built on interdependence among its members

For we humans, the most important part of the ecosystem that we live in is definitely the other human beings who live in it. We have thus developed a strong interdependence by discovering, at a very early age, our need to cooperate with one another and the benefits that this cooperation brings. If you need any proof how much human children are naturally inclined to help one another, all you need do is watch the videos shot by psychologist Michael Tomasello . (more…)

Emotions and the Brain, From Thought to Language | Comments Closed